《生命科学》 2017, 29(10): 1025-1032

表观遗传调控在胚胎干细胞命运决定中的作用及机制

肖　峰，金　颖*

(中国科学院上海生命科学研究院中科院干细胞重点实验室，上海 200031)

摘　要：摘　要：胚胎干细胞(embryonic stem cells， ESCs) 具有无限自我更新和发育多能性两大特性，可为基础研究、药物筛选及再生医学等提供无限的细胞来源。ESC 的命运决定受多个层次的调控，主要包括信号通路、转录因子和表观遗传。越来越多的研究表明，表观遗传调控在ESC 命运决定中发挥着重要作用，然而，其中的分子机制仍不是十分清楚，需要进一步揭示。以基金委重大研究计划“ 细胞编程和重编程的表观遗传机制” 为依托，金颖实验室从表观遗传角度揭示ESC 自我更新和发育多能性的分子调控机制，取得了多项重要进展。现主要对此研究计划中金颖实验室的原创性工作进行综述。

The function and mechanism of epigenetic regulation in the control of embryonic stem cell fate

XIAO Feng， JIN Ying*

(CAS Key Stem Cell Biology Laboratory， Shanghai Institutes for Biological Sciences，
    Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Unlimited self-renewal and pluripotency are hallmarks of embryonic stem cells (ESCs)， providing unlimited cell sources for basic research， drug screening， and regenerative medicine. The unique properties of ESCs are controlled by multiple regulatory mechanisms， including those mediated by signaling pathways， transcription factors and epigenetic regulators. Though more and more studies have demonstrated important roles of epigenetic regulation in ESC fate determination， the underlying mechanism is not fully understood. Supported by grants from the Major Research Program “The Epigenetic Mechanism of Cell Programming and Reprogramming” of the National Natural Sciences Foundation of China (NSFC)， we have achieved several important progresses from the perspective of epigenetic regulation in ESC fate determination. In this review， we summarize our original works supported by the Major Research Program funded by NSFC.