《生命科学》 2017, 29(8): 785-789

蓝藻生物钟信号输出途径分子机制的研究进展

魏琳子1，吴　越1，陈　强1，2，刘　森1，2*

(1 三峡大学医学院，宜昌 443002；2 肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002)

摘　要：摘　要：昼夜节律生物钟包括信号输入途径、核心振荡器和信号输出途径。在生物钟振荡周期与环境信号的同步过程中，信号输入途径感应外界环境的时间变化信号致使生物钟振荡周期和环境同步，并将其输入途径接受的外界信息传递给核心振荡器，核心振荡器再通过不同输出途径将周期性时间信号传递出去，产生周期性的信号调控作用。主要对蓝藻生物钟已知的三条主要输出途径KaiC-SasA-RpaA、KaiC-LabARpaA和KaiC-CikA-RpaA 及其相关调节因子的分子机制研究进展进行综述。

Progress in the molecular mechanism of the output pathways of the cyanobacterial circadian clock

WEI Lin-Zi1， WU Yue1， CHEN Qiang1，2， LIU Sen1，2*

(1 College of Medical Science， China Three Gorges University， Yichang 443002， China; 2 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy， Yichang 443002， China)

Abstract: Abstract: Circadian clocks in organisms have three relatively independent modules: the signal input module， the core oscillator， and the signal output module. During the entrainment of a circadian clock， the timing signals from the external environment are received by the signal input module and then relayed to the core oscillator， which synchronizes the period of the circadian oscillator with that of the environmental cues. In this process， the core oscillator disseminates the rhythmical information via different signal output modules/pathways to rhythmically modulate downstream signals. This review summarized the recent progress in the molecular mechanism of three major signal output pathways of the cyanobacteria， including KaiC-SasA-RpaA， KaiC-LabA-RpaA， and Kaic-CikA-RpaA.