《生命科学》 2017, 29(8): 779-784

抑郁症与生物节律紊乱的相关性研究进展

张婉菁，陆　平，吴　涛，傅正伟，倪银华*

(浙江工业大学生物工程学院，杭州 310014)

摘　要：摘　要：生物钟的正常运行使得细胞以及组织的活性和功能得以有序进行，从而保证机体功能更好地适应环境的变化。研究发现，抑郁症的发病机制与生物钟的紊乱有关。抑郁症不仅会对患者自身的情绪造成巨大影响，对机体内部的生物节律也会产生影响；而生物钟基因的多态性以及生物钟对单胺类神经递质、下丘脑- 垂体- 肾上腺轴和神经信号通路的调控，在抑郁症的发病过程中起着重要作用。因此，利用生物节律的变化可以作为治疗抑郁症的重要手段，包括光疗法、剥夺睡眠、睡眠/ 觉醒相位提前、联合疗法以及时间药理学的应用。

Progress of the relationships between depression and circadian rhythm disorder

ZHANG Wan-Jing， LU Ping， WU Tao， FU Zheng-Wei， NI Yin-Hua*

(College of Biotechnology and Biological Engineering， Zhejiang University of Technology， Hangzhou 310014， China)

Abstract: Abstract: The circadian clock coordinates activities and functions in cells and tissues to optimize body functions to adapt daily changes in the environment. It has been known that the pathogenesis of depression is related with the disruption of circadian rhythm. In addition to the mood regulation， depressive disorder also plays a critical role in the regulation of internal circadian rhythm. On the other hand， clock gene polymorphism， clock regulation of monoamine signaling， the hypothalamic-pituitary-adrenal axis and neuronal signaling are involved in the development of depression. Therefore， manipulation of the circadian cycle could be used as treatments for depressive disorder， which include bright light therapy， sleep deprivation， phase advance of the sleep/wake cycle， combination treatment and chronopharmacology.