《生命科学》 2017, 29(5): 514-520

大肠杆菌耐药现状的严峻性

高海涛1，2，韩俊丽1，关道明2*

(1 大连海洋大学，大连 116023；2 国家海洋环境监测中心，大连 116023)

摘　要：摘　要：耐药性是指微生物对抗菌类药物的耐受性，微生物的耐药性会使药物的治疗效果明显下降。目前，我国和世界范围内的大肠杆菌的耐药性比较严重，在南北极环境中也检测到了耐药性的大肠杆菌。现概述了国内外临床、养殖、两极等环境中大肠杆菌的耐药现状，讨论了耐药性大肠杆菌存在的严峻性和耐药性大肠杆菌扩散的危害。耐药性大肠杆菌的现状十分严峻，所以，加强和完善对抗生素的管控和建立快速耐药性检测的方法尤为重要。另外，创新研发新型抗菌药物和多学科开展协同研究共同面对严峻的大肠杆菌耐药的现状。

The grim situation of drug resistance in Escherichia coli

GAO Hai-Tao1，2， HAN Jun-Li1， GUAN Dao-Ming2*

(1 Dalian Ocean University， Dalian 116023， China; 2 National Marine Environmental Monitoring Center， Dalian 116023， China)

Abstract: Abstract: Antibiotic tolerance is also called antibiotic resistance， including the natural resistance and acquired antibiotic resistance， which signify the tolerance of the microorganism to antibacterial antibiotics. The antibiotic resistance of E. coli has become a major threat to human health worldwide， and antibiotic-resistant E. coli was isolated in the Arctic and Antarctic. This review focus on the occurrence， distribution， horizontal transfer and mechanism of antibiotic-resistant E. coli in domestic， clinical and polar region. Therefore， with the aim to effectively control the emergence of antibiotic-resistance， the dissemination and mechanism of antibiotic resistance need to be understood. Additionally， the development of novel antibiotic agents also should take into account.