《生命科学》 2017, 29(2): 153-159

蛋白酪氨酸硫酸化修饰的研究进展

潘露露，翟琳辉*，谭敏佳

(中国科学院上海药物研究所新药研究国家重点实验室，上海 201203)

摘　要：摘　要：无机硫酸盐与生物分子的结合在生物体系中具有重要的作用，并且与疾病的发生直接相关。蛋白酪氨酸硫酸化(protein tyrosine sulfation， PTS) 是一个普遍的翻译后修饰，从其第一次被报道至今已有50 余年。然而，酪氨酸硫酸化在生理条件下的意义以及与疾病的关系在最近几年才逐渐受到关注。目前，只有极少量的硫酸化蛋白质得以鉴定。现选择性地对蛋白酪氨酸硫酸化做一个简要的回顾，并总结了基本的生物化学信息，包括酪氨酸蛋白硫酸转移酶的制备、蛋白酪氨酸硫酸化的测定方法、蛋白酪氨酸硫酸化的生物学功能。这些信息是将来对蛋白酪氨酸硫酸化功能进一步探索的基础。

Research progress on protein tyrosine sulfation

PAN Lu-Lu， ZHAI Lin-Hui*， TAN Min-Jia

(State Key Laboratory of Drug Research， Shanghai Institute of Materia Medica，
    Chinese Academy of Science， Shanghai 201203， China)

Abstract: Abstract: The combination of inorganic sulfate and biological molecules plays a significant role in biological systems， which is directly related to the occurrence of diseases. Protein tyrosine sulfation (PTS) is a common posttranslational modification which has been researched more than fifty years. However， the function of protein tyrosine sulfation and its relationship with the diseases begun to get attention in recent years. At present， only a small part of sulfated proteins has been identified. In this paper， we selectively make a brief review on protein tyrosine sulfation， including the preparation of tyrosylprotein sulfotransferase， the determination methods for protein tyrosine sulfation， and the biological functions of protein tyrosine sulfation. This knowledge is basic for the future exploration of the function of protein tyrosine sulfation.