《生命科学》 2017, 29(1): 52-54

睾丸微环境对精子发生及其异常的调控作用

海亚楠，袁青青，孙　敏，牛明辉，郭　英，何祖平*

(上海交通大学医学院附属仁济医院，癌基因与相关基因国家重点实验室， 仁济医院-Med X临床干细胞研究中心，上海 200127)

摘　要：摘　要：男性不育已经成为影响人类生殖健康的重大疾病。精子发生是精原干细胞自我更新和分化为精子的复杂过程。这个过程受睾丸微环境的精细调控。将讨论精子发生与睾丸微环境的关系，简要介绍睾丸微环境的国内外研究动态，展望睾丸微环境的研究热点和前沿。这将为阐释精子发生的机制提供新的调控机理，对治疗男性不育，预防子代出生缺陷，研发新型男性避孕方法等都具有重要意义。

The roles of testicular microenvironment in regulating normal    and abnormal spermatogenesis

HAI Ya-Nan， YUAN Qing-Qing， SUN Min， NIU Ming-Hui， GUO Ying， HE Zu-Ping*

(State Key Laboratory of Oncogenes and Related Genes， Renji- Med X Clinical Stem Cell Research Center， Ren Ji Hospital， School of Medicine， Shanghai Jiao Tong University， Shanghai 200127， China)

Abstract: Abstract: Male infertility has become one of the most serious diseases affecting human reproduction and health. Spermatogenesis is a complex process by which spermatogonial stem cells self-renew and differentiate to mature spermatids. This process is precisely regulated by the microenvironment of the testis. In this review， we addressed the relationship between spermatogenesis and testicular microenvironment as well as the advancement on the testicular microenvironment. We highlighted the frontier and hot topics in the studies on testicular microenvironment. These studies would provide novel mechanisms underlying spermatogenesis and are of great significance in treating male infertility， preventing defect of offspring， and developing new approaches for male contraceptives.