《生命科学》 2016, 28(1): 107-111

哺乳动物卵巢生殖干细胞的研究进展与争议

赵琰誉，刘　英*

(首都医科大学附属北京妇产医院生殖医学科，北京 100026)

摘　要：摘　要：关于雌性哺乳动物卵子再生的问题一直存有争议，1951 年后人们普遍认为卵子数会随年龄增长而下降，不存在再生。近年来有学者对此提出质疑，他们在研究小鼠卵子凋亡时发现，卵巢内可能存在具有有丝分裂活性的生殖干细胞，随即引起了激烈讨论。虽然有一些实验结果对卵巢生殖干细胞的存在提出质疑，但是越来越多的研究提供了其存在的证据。卵巢生殖干细胞的研究一旦成熟，对基础及临床将具有深远影响。现对卵巢生殖干细胞的发现和研究现状及潜在应用展开综述。

Research progress and controversy of ovarian germ stem cells in mammals

ZHAO Yan-Yu， LIU Ying*

(Department of Reproductive Medicine， Beijing Obstetrics and Gynecology Hospital，
    Capital Medical University， Beijing 100026， China)

Abstract: Abstract: It is generally believed that postnatal female mammals had definite ovarian reserve and the follicles decreased with age. However in recent years， studies have shown that cells with mitotic activity may exist in mouse ovaries. Although the existence of ovarian germline stem cells is still unresolved at present， there is a growing number of studies revealing that female mammals may have a population of renewable cells in the ovaries. Once the research of ovarian germline stem cells has matured， it may have a profound impact on basic and clinical medicine. In this review， we mainly reviewed the history and current study development of ovarian germline stem cells in postnatal female mammals.