《生命科学》 2015, 27(11): 1462-1468

生物钟与男性生殖研究进展

马用信

(四川大学华西医院医学遗传研究室暨生物治疗国家重点实验室，疾病基因组学研究室，成都 610041)

摘　要：摘　要：生物钟现象存在于几乎所有生命体中，对多种生理活动和生物行为产生影响。除了中枢神经系统外，生物钟基因还广泛表达于包括睾丸在内的多种外周组织当中，提示其在男性生殖中具有重要功能。生物钟失调乃至于单个生物钟基因的缺失或突变，不仅会对生命体的行为活动产生影响，还可能对其生殖能力造成损害。近年来，男性生殖健康的问题越来越受到社会的关注，深入研究生物钟与男性生殖之间的关系，具有重要的研究意义和广泛的应用前景。

Circadian rhythm and male reproduction

MA Yong-Xin

(Department of Medical Genetics and Division of Morbid Genomics， State Key Laboratory of Biotherapy， West China Hospital， Sichuan University， Chengdu 610041， China)

Abstract: Abstract: The circadian rhythm is involved in a variety of physiological and behavioral activities of almost all organisms. Clock genes are widely expressed not only in the central nervous system but also in many peripheral tissues including testis， suggesting that they may play important roles in male reproduction. Disorders of circadian rhythm， as well as deficiencies or mutations in single clock genes， may impair male reproductive functions. Male reproductive health has been paid great attention to in modern societies， it is certainly time to consider seriously the relationship between circadian rhythm and male reproduction.