《生命科学》 2015, 27(11): 1455-1461

哺乳类动物生物周期节律对动脉粥样硬化的调控机制

唐清明#，翁秀红#，程　波*

(华中科技大学同济医学院附属协和医院口腔科，武汉 430022)

摘　要：摘　要：生物周期节律(circadian rhythms) 是指机体内生命活动随时间节律性变化的规律。相关研究证实哺乳动物心血管系统的功能活动存在昼夜周期节律变化，而生物周期节律紊乱也参与动脉粥样硬化(atherosclerosis， AS) 的发生、发展。哺乳动物心血管系统中生物周期节律紊乱会破坏血管壁细胞生理功能，改变血流状态，诱发血管炎症反应，影响内皮源性一氧化氮(nitric oxide， NO) 的合成与释放等，从而促进斑块的形成和发展，诱发斑块的不稳定，对AS 的发生、发展具有重要的作用。现总结近年来生物节律与AS 的研究进展，探讨哺乳动物心血管系统生物周期节律的表现形式以及节律紊乱对AS 的调控机制，以期为AS 的防治提供新的思路。

The regulation mechanisms of mammalian circadian rhythms on atherosclerosis

TANG Qing-Ming#， WENG Xiu-Hong#， CHENG Bo*

(Department of Stomatology， Wuhan Union Hospital， Tongji Medical College， Huazhong University of Science and Technology， Wuhan 430022， China)

Abstract: Abstract: It has been confirmed that functional activities in mammalian cardiovascular system displayed circadian oscillations， which means regular pattern of living activities， publicly， it also named circadian rhythms. Furthermore， it implicated that circadian rhythms dysregulation plays a critical role in the pathogenesis of atherosclerosis. Moreover， it contributed to cardiovascular diseases via its regulatory effect on physical function of vessel，haemodynamics， inflammatory response and endothelium-derived NO synthesis and release， resulting in plaque formation and instability which participated in atherosclerosis process. In this review， the current understanding of the circadian rhythms in mammalian cardiovascular system and its roles in atherosclerosis were both discussed in order to make full understanding in the mechanism of atherosclerosis.