《生命科学》 2015, 27(11): 1433-1440

生命中不能承受之轻——微重力条件下生物昼夜节律的变化研究

梁小弟¹ , 刘志臻² , 陈现云¹ , 吕　柯³ , 陈善广² , 郭金虎^1,*

¹中山大学生命科学学院基因工程教育部重点实验室，有害生物控制与资源利用国家重点实验室，广州 510006 ²中国航天员科研训练中心人因工程重点实验室，北京 100094 ³中国航天员科研训练中心航天医学基础与应用国家重点实验室，北京 100094

摘　要：

摘　要：生物钟是地球上绝大多数生物经过长期演化形成的一种内在机制，可以调控生物的生理、代谢和行为的节律，以适应地球因自转而产生的近24 小时的昼夜周期。人类在空间探索过程中由于环境因素与地表环境的巨大差异，生理和健康面临很大的压力。在诸多环境因子中，重力变化对生物钟具有重要的影响。迄今人们已对人及多种生物在微重力环境中的变化规律进行了研究，但微重力调控生物钟的分子机制仍很不清楚。现将对此方面的研究概况和进展进行综述。

通讯作者：郭金虎 , Email:guojinhu@mail.sysu.edu.cn

Unbearable lightness of being - the changes in circadian rhythms under microgravity

LIANG Xiao-Di¹ , LIU Zhi-Zhen² , CHEN Xian-Yun¹ , LV Ke³ , CHEN Shan-Guang² , GUO Jin-Hu^1,*

¹Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China ²Human Factor Laboratory, Astronaut Center of China, Beijing 100094, China ³State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China

Abstract:

Abstract: The internal circadian clocks have been evolved in the vast majority of life forms on the Earth， which allow organisms to synchronize their physiology， metabolism and behavior to ca. 24-h periodic changes in environment factors caused by the Earth self-rotation. The distinct differences in environmental factors in space bring about remarkable challenges for space exploration， which dramatically influences physiology， metabolism and behavior of the astronauts. Amongst numerous environmental factors， alteration in gravity has considerable impacts on a lot of physiological variables including circadian rhythms. Though many studies have shed light on changes of the circadian clock in humans and other species under microgravity， the underlying molecular mechanism is largely unclear. Here we review advances regarding the impacts of microgravity on circadian clocks.

Communication Author：GUO Jin-Hu , Email:guojinhu@mail.sysu.edu.cn