《生命科学》 2015, 27(11): 1386-1391

进食行为调控外周生物钟节律的研究进展

孙秀杰，陈亚琼，刘　浥*

(中国科学院上海生命科学研究院，营养科学研究所，营养与代谢重点实验室，上海 200031)

摘　要：摘　要：哺乳动物的生物钟包括位于下丘脑视交叉神经上核中的中枢生物钟(central clock) 以及外周组织生物钟(peripheral clock)。节律正常时，由中枢时钟决定的外周生物钟同时具有一定程度的独立性。食物牵引实验(food entrainment) 证明改变进食时间( 白天给食) 可以完全逆转外周组织的节律，因此，对于外周组织，进食是一个重要的授时因子(synchronizer)。目前已报道多种进食相关信号调控外周生物钟基因的表达及节律。现就进食行为影响外周生物钟等方面的研究进行综述。

The mechanism of food entrainment modulating peripheral clocks

SUN Xiu-Jie， CHEN Ya-Qiong， LIU Yi*

(Key Laboratory of Nutrition and Metabolism， Institute for Nutritional Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: The mammalian circadian clock is composed by central clock， located at hypothalamic suprachiasmatic nucleus (SCN)， and diverse peripheral clocks in variable tissues. Under the control of master central clock， the rhythm of peripheral clocks is necessary for tissue-specific oscillations that control circadian physiology of tissues. Accumulating evidences support the notion that metabolism， food consumption， timed meals and some nutrients feedback to regulate the peripheral rhythmicity. This review summarize the recent findings concerning the molecular mechanism of feeding entrainment modulating peripheral clock.