《生命科学》 2015, 27(10): 1218-1221

心律失常发生的核受体调控机制研究进展

解端阳1，2，李　俊1，2，3*

(1 同济大学医学院病理与病理生理学系，上海 200092；2 心律失常教育部重点实验室(同济大学)，上海 200092；3 同济大学附属东方医院心脏内科，东方转化医学研究中心，上海 200120)

摘　要：摘　要：心律失常是一种心脏电活动起源或者转导障碍导致的心脏疾病，其发生发展的分子机制尚不明确。心肌细胞表面膜离子通道与缝隙连接通道蛋白的表达及功能关键性地决定了心脏电活动的稳态。核受体家族(nuclear receptor family) 是一组配体激活的转录因子家族，配件包括固醇类激素、维生素D、甲状腺激素等。它们定位于细胞核，在离子通道和缝隙连接蛋白的转录、转运和功能调节中发挥重要的作用。现就近年来核受体调控心律失常发生发展的相关报道做一综述。

Regulatory mechanisms of nuclear receptors for arrhythmogenesis

XIE Duan-Yang1，2， LI Jun1，2，3*

(1 Department of Pathology and Pathophysiology， School of Medicine， Tongji University， Shanghai 200092， China; 2 Key Laboratory of Arrhythmias of the Ministry of Education of China， Tongji University， Shanghai 200092， China; 3 Research Center for Translational Medicine， Department of Cardiology， East Hospital， Tongji University， Shanghai 200120， China)

Abstract: Abstract: Cardiac arrhythmias are characterized by disorders of heart beating frequency and rhythm， which are derived from abnormal electrical excitation and conduction in the heart. Generally， the expression and function of sarcolemmal ion channels and intercellular connexin channels critically determine cardiac electrophysiological homeostasis. The nuclear receptors belong to a transcriptional factor family that is activated by steroid hormones， vitamin D and thyroid hormones. They are localized in the nucleus. Through establishing links between signaling molecules and transcription response， they regulate the transcription， transport and function of the above-mentioned channels. Herein we review the recent studies on nuclear receptors involved in regulating occurrence and development of cardiac arrhythmias.