《生命科学》 2015, 27(3): 322-326

精确医学为老药新用及联合用药带来新契机

盛苗苗，蒋澄宇*

(中国医学科学院基础医学研究所&北京协和医学院基础学院，医学分子生物学国家重点实验室，北京 100050）

摘　要：摘　要：老药已在临床上应用，其物化、药代和安全性应有保障，新用途的开发可以大大节约研发周期和成本，因此老药新用以及联合用药被认为是新药开发中最快捷、最有效的策略之一。随着组学技术的长足发展，人类医学开始进入“精确医学时代”，为老药新用以及联合用药的快速开发提供了广阔的应用前景。就老药新用的发展、意义以及组学技术对老药新用的促进作用进行综述。

Precision medicine brings new opportunities for repurposing drugs and drugs combination

SHENG Miao-Miao， JIANG Cheng-Yu*

(State Key Laboratory of Medical Molecular Biology， Institute of Basic Medical Sciences， Chinese Academy of Medical Sciences; Department of Biochemistry and Molecular Biology， Peking Union Medical College， Tsinghua University， Beijing 100050， China)

Abstract: Abstract: The old drugs have been used in clinical trials， its physicochemical properties， pharmacokinetics and safety should be guaranteed， repositioning the existing drugs for new indications can save costs and time in drug development， so repurposing drugs and drugs combination are considered to be one of the quickest and most effective strategies in the field of drug discovery. With the rapid development of Omics， human medicine begins to enter the “precision medicine era”， which will provide a broad application prospect for repurposing drugs and drugs combination. This review focuses on the development and significance of repurposing drugs and promoting effect of Omics on repurposing drugs.