《生命科学》 2014, 26(10): 1090-1095

蜘蛛抗菌肽研究进展

唐　兴*，陈连水，李　江

(东华理工大学化学生物与材料科学学院，南昌 330013)

摘　要：摘　要：蜘蛛活性多肽研究主要集中于蜘蛛毒液中作用于离子通道的神经毒素多肽。但近年来，一些蜘蛛抗菌肽不断被分离纯化，其结构和抗菌活性也被广泛深入研究，这将成为蜘蛛活性多肽研究领域的一个新热点。在蜘蛛毒液和血液中，存在不同种类的抗菌肽，其多肽长度、结构、抗菌作用各不相同。而且，有些抗菌肽甚至具有抗肿瘤作用。概述了蜘蛛抗菌肽在结构和功能方面的研究进展。

Advances in spider antimicrobial peptides

TANG Xing*， CHEN Lian-Shui， LI Jiang

(College of Chemistry， Biology， and Material Science， East China Institute of Technology， Nanchang 330013， China)

Abstract: Abstract: Researches in spider active peptides are mainly focused on venom peptides that affect neuronal ion channels. However， in recent years， some spider antimicrobial peptides have been isolated and purified， and their structures and antibacterial activities have been widely and deeply studied. Spider antimicrobial peptides will be a new hotspot in this field. Various antimicrobial peptides are isolated from spider venom and blood with different peptide length， structure， and antibacterial effect. Moreover， some spider antimicrobial peptides exhibit cytotoxic activity against tumor cells. This review presents the research progress on structure and function of spider antimicrobial peptides.