《生命科学》 2014, 26(10): 1067-1072

乳腺癌干细胞分选及相关信号通路研究进展

吴海歌*，吴　晨，姚子昂，高晨慧，李　倩

(大连大学生命科学与技术学院，大连 116622)

摘　要：摘　要：肿瘤干细胞是指存在于肿瘤组织中的具有干细胞特性，即能够多向分化和自我更新的一类细胞群。随着肿瘤干细胞概念的提出，乳腺癌干细胞成为当今科研领域的一个研究热点。因此，了解如何分选乳腺癌干细胞及如何维持其“干性”对治疗及预防乳腺癌具有至关重要的意义。主要从乳腺癌干细胞分选、相关信号通路、上皮- 间充质转换(EMT) 等方面进行综述。

Progress in the sorting and signaling pathways of breast cancer stem cells

WU Hai-Ge*， WU Chen， YAO Zi-Ang， GAO Chen-Hui， LI Qian

(School of Life Science and Technology， Dalian University， Dalian 116622， China)

Abstract: Abstract: Cancer stem cells are a group of cells in tumor tissue which have properties of stem cells and the ability of both mlti-directional differentiation and self-renewing. In recent years， with the concept of cancer stem cells proposed， much work has been focused on breast cancer stem cells (BCSC). Understanding how to sorting BCSC and how to maintain the "stem" is crucial for treatment and prevention of breast cancer. In this paper， the progress in sorting of BCSC， related signaling pathways and epithelial-mesenchymal transition (EMT) is summarized.