《生命科学》 2014, 26(10): 1012-1017

蛋白4.1家族在神经系统中的研究进展

荔　辉1，张　彬2，王　梓1，周卫华1，刘　静1，3*

(1 中南大学生命科学学院分子生物学研究中心，长沙 410078；2 中南大学基础医学院
    组胚教研室，长沙 410013；3 中南大学医学遗传学国家重点实验室，长沙 410078)

摘　要：摘　要：蛋白4.1 家族是细胞骨架蛋白，包括4.1N、4.1B、4.1G 和4.1R 四个成员，含有膜结合结构域、血影蛋白- 肌动蛋白结合结构域和C 端结构域3 个高度保守的结构和功能域。蛋白4.1 家族在人体包括神经系统等多种组织中表达。对蛋白4.1 家族在神经系统Ca2+ 信号转导、受体通道定位与转运、髓鞘等多种重要结构形成中的重要作用进行综述。近来，蛋白4.1 家族发挥抑癌基因作用也引起了广泛关注。

Research progress of protein 4.1 family in nervous system

LI Hui1， ZHANG Bin2， WANG Zi1， ZHOU Wei-Hua1， LIU Jing1，3*

(1 Molecular Biology Research Center， School of Life Sciences， Central South University， Changsha 410078， China; 2 Department of Histology and Embryology， Xiangya School Medicine， Central South University， Changsha 410013， China; 3 State Key Laboratory of Medical Genetics， Central South University， Changsha 410078， China)

Abstract: Abstract: The protein 4.1 family is an important membrane skeleton protein. This family contains four homologous proteins: 4.1N， 4.1B， 4.1G and 4.1R. Each member of the protein 4.1 family is characterized by three highly conserved structural and functional domains: membrane binding domain， spectrin-actin binding domain and carboxyl terminal domain. Protein 4.1 family members are expressed in various cells and tissues including nervous system. They not only play several important roles in the morphological development and stability of nervous system， but also take part in receptor channel location and transportation. Moreover， they mediate the regulation of development and formation of myelin sheath and Ca2+ signal transduction. Lots of reports indicated that protein 4.1 families may act as tumor suppressor genes.