《生命科学》 2014, 26(9): 967-973

miRNA在疼痛相关离子通道及受体中的作用研究

邱 　芳1，刘玉强2，胡旺平3，杨之帆1*

(1 湖北大学生命科学学院， 武汉 430062；2 武汉大学基础医学院生理学系， 武汉 430071；3 湖北科技学院药学院，咸宁 437000)

摘　要：miRNA 广泛表达于神经系统，与疼痛的发生、发展密切相关。近年来研究表明，抑制miRNA 的合成调制伤害性神经元对炎症刺激的反应。疼痛时，背根神经节(DRG) 上miRNA 明显下调，该变化参与炎性疼痛和神经性疼痛的产生和维持。同时，miRNA 也可以下调Navα 亚基、ASIC3、 TRPV1 和P2X7mRNA 的表达水平，还可以降低Kv 电流。因此，miRNA 可能成为疼痛治疗的新靶点。综述了miRNA 的生物起源、分布，及其对痛觉相关离子通道Nav、Kv、ASICs、TRPV1 以及嘌呤受体的调节作用。

The role of miRNA in pain-related ion channels and receptors

QIU Fang1， LIU Yu-Qiang2， HU Wang-Ping3， YANG Zhi-Fan1*
    

(1 Colllege of Life Sciences， Hubei University， Wuhan 430062， China; 2 Department of Physiology， School of Basic Medical Sciences， Wuhan University， Wuhan 430071， China; 3 Department of Pharmacology， Hubei University of Science and Technology， Xianning 437100， China)

Abstract: miRNA is widely expressed in the nervous system and is closely related to the genesis and development of pain. Recently， studies have demonstrated that inhibition of miRNA synthesis can mediate the response of nocieptive nerve to inflammatory stimulation. In the dorsal root ganglion (DRG)， miRNA is greatly down-regulated following pain， which is involved in the induction and maintenance of inflammatory and neuropathic pain. Meanwhile， miRNA can decrease the mRNA expression levels of the Navα subunits， ASIC3， TRPV1 and P2X7， and down-regulate the current of Kv. So miRNA may provide a novel target for the treatment of pain. This article highlights the miRNA biogenesis， distribution， and its significant role in pain-related ion channels (Nav， Kv， ASICs， TRPV1 and purinergic receptor).