《生命科学》 2014, 26(9): 912-917

模式识别受体介导的病原免疫逃逸

胡茂志1，2，潘志明1，2，焦新安1，2*

(1 扬州大学江苏省高校动物重要疫病与人兽共患病防控协同创新中心，扬州 225009；
    2 扬州大学江苏省人兽共患病学重点实验室，扬州 225009)

摘　要：天然免疫通过细胞模式识别受体识别病原相关分子模式来清除感染。但是，在长期的进化过程中，许多病原体已经形成了自身的保护机制，从而逃逸天然免疫的杀伤。综述了模式识别受体介导的病原体的主要逃逸机制，以期为疾病的控制和预防提供新认识。

Escape mechanisms of pathogen mediated by pattern-recognition receptors

HU Mao-Zhi1，2， PAN Zhi-Ming1，2， JIAO Xin-An1，2*

(1 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses， Yangzhou University， Yangzhou 225009， China; 2 Jiangsu Key Laboratory of Zoonosis， Yangzhou University， Yangzhou 225009， China )

Abstract: Innate immunity can clear the pathogen through the recognition of pathogen-associated molecular pattern recognition receptors (PRRs). But， in the long-time evolutionary process， many pathogens have developed some protective mechanisms to escape the killing of innate immunity. Here， we reviewed the research progress on escape mechanisms of pathogens mediated by PRRs， in order to benefit the control and prevention of diseases.