《生命科学》 2014, 26(9): 897-902

非编码RNA在胞内病原菌免疫逃逸与致病中的作用

杜崇涛，张晓静，杨　梅，刘宏涛，冯世源，韩文瑜*

(吉林大学动物医学学院，长春 130062)

摘　要：非编码RNA(non-coding RNAs， ncRNAs) 在细胞增殖、发育、分化、代谢、信号转导以及免疫调控中发挥重要调节作用。越来越多的研究证明，ncRNA 在胞内病原菌的致病性和免疫逃逸中发挥重要调控作用。一方面ncRNA 是细菌代谢、群体感应和毒力因子表达的调控因子，与胞内病原菌的致病性密切相关；另一方面ncRNA 在调节宿主抗胞内病原菌免疫应答中发挥重要作用，深入研究ncRNA 如何调节宿主免疫应答将有助于胞内菌免疫逃逸机制的研究。就非编码RNA在胞内病原菌免疫逃逸和致病中的作用作一综述。

The role of small non-coding RNA in intracellular bacterial immune escape and pathogenicity

DU Chong-Tao， ZHANG Xiao-Jing， YANG Mei， LIU Hong-Tao， FENG Shi-Yuan， HAN Wen-Yu*

(College of Veterinary Medicine， Jilin University， Changchun 130062， China)

Abstract: Non-conding RNAs (ncRNAs) are shown to be involved in eukaryotic growth and development， cell proliferation and differentiation， metabolism， cell signalling and immune response. Accumulated references have shown that ncRNAs are emerging as one of the crucial regulators in bacterial immune escape and virulence. On one hand， ncRNAs modulate bacterial pathogenicity via post-transcriptional regulation of bacterial metabolism， quorum sensing and virulence factors expression. On the other hand， ncRNAs regulate immune response against intracellular bacterial infection. Understanding how the immune response is regulated by ncRNAs during infection will facilitate the immune escape mechanism against intracellular bacteria. A brief review on the role of ncRNAs in intracellular bacterial immune escape and pathogenicity is given in this article.