《生命科学》 2014, 26(8): 809-813

抗菌肽抗肿瘤作用的研究进展

夏丽洁，张富春*

(新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室，乌鲁木齐 830046)

摘　要：摘　要： 抗菌肽是生物体抵御外界病原体侵袭时产生的一类保守的小分子多肽，是生物体内先天免疫防御机制的重要组分。抗菌肽可以选择性杀伤肿瘤细胞，而对正常细胞损害较小，已作为化、放疗药物潜在的替代品被广泛研究和开发。从抗菌肽对不同肿瘤细胞选择性作用机制、抗菌肽药物设计的发展及应用前景等方面进行综述。

Research progress on antitumor effects of antimicrobial peptides

XIA Li-Jie， ZHANG Fu-Chun*

(Xinjiang Key Laboratory of Biological Resources and Genetic Engineering， College of Life Science and Technology， Xinjiang University， Urumqi 830046， China)

Abstract: Abstract: Antimicrobial peptides， a class of conserved small-molecule peptides， are important components of the innate defense system of organism to resist outside pathogen invasion. Antimicrobial peptides are active against cancer cells while not active against healthy mammalian cells. Considerable effort has been made to exploit their attractive candidate for novel therapeutic approaches. This review focused on the selectivity of antimicrobial peptides toward different tumor cells and relative mechanisms of action， and described the development of antimicrobial drug design and application prospects.