《生命科学》 2014, 26(3): 295-301

维甲酸及其受体与肿瘤关系的研究进展

孙宇强¹，王　雪²，关兴芳³，李德胜¹，舒晓宏²，李墨林^4*

(1 大连医科大学2009级七年制学生，大连 116044；2 大连医科大学药学院，大连 116044；3 大连医科大学2010级医疗系英文班学生，大连 116044；4 大连医科大学病理生理学教研室，大连 116044)

摘　要：维甲酸(retinoic acid， RA) 是维生素A 的活性代谢产物，全反式维甲酸(all-trans-retinoic acid， ATRA)、13- 顺式维甲酸(13-cis-retinoic acid， 13-cRA) 和9- 顺式维甲酸(9-cis-retinoic acid， 9-cRA) 等是其同分异构体。维甲酸通过与其受体包括维甲酸受体和维甲酸X 受体结合调控靶基因表达，在胚胎发育和细胞的生长及分化过程中发挥重要作用。全反式维甲酸治疗急性早幼粒白血病开创了分子靶向药物诱导肿瘤细胞分化治疗的先河，目前研究发现，维甲酸及其受体与肿瘤细胞的分化、增殖或凋亡等密切相关。就维甲酸及其受体与肿瘤关系的研究进展进行综述，为进一步研究奠定基础。

Advanced progress on the relationship between RA and its receptors and malignant tumors

SUN Yu-Qiang¹， WANG Xue²， GUAN Xing-Fang³， LI De-Sheng¹， SHU Xiao-Hong²， LI Mo-Lin^4*

(1 2009 Seven-year Program Medical Students， Dalian Medical University， Dalian 116044， China; 2 College of Pharmacy， Dalian Medical University， Dalian 116044， China; 3 2010 Medical Students of Dalian Medical University， Dalian 116044， China; 4 Department of Pathophysiology， Dalian Medical University， Dalian 116044， China)

Abstract: Retinoic acid is an active derivative of vitamin A. ATRA， 13-cRA and 9-cRA are the isomers of retinoids. Combining with RARs and RXRs， RA plays important roles in embryonic development， cell growth and differentiation through regulating the target gene expression. ATRA has been successfully used in the differentiation therapy of APL (acute promyelocytic leukemia) in clinical. Current studies have found that the disturbance of RA and its receptors were also related to differentiation， proliferation or apoptosis of tumor cells. To develop novel mechanisms-based differentiation therapy， the relationship between RA or its receptors and tumors will be summarized in this review.