《生命科学》 2013, 25(9): 878-885

RPE细胞的正常功能及其在眼科疾病中的作用

王海青¹，牛国桢²，张晓波²，麻晓银^2*

(1 温州医科大学附属第一医院生殖中心，温州 325035； 2 温州医科大学附属眼视光医院， 温州 325035)
    

摘　要：摘　要： 视网膜色素上皮(retinal pigment epithelium， RPE) 细胞在眼的发育和视觉功能中起着重要的作用，具有分泌生长因子、抗氧化、参与视循环代谢、维持血- 视网膜屏障和吞噬视细胞脱落的外节盘膜等重要生理功能。RPE 细胞的正常结构和功能为视网膜感光细胞的正常发育及功能发挥所必需，若RPE 细胞出现结构或功能异常则会导致视网膜感光细胞功能受损、视网膜退化等疾病。鉴于其重要性，就RPE 细胞的发育、正常结构和功能进行综述，为其相关眼科疾病的治疗提供一定的依据。
    关键词：视网膜病变；RPE ；色素细胞；眼科

The normal functions of RPE cell and its roles in eye disease

WANG Hai-Qing¹， NIU Guo-Zhen²， ZHANG Xiao-Bo²， MA Xiao-Yin^2*

(1 Reproductive Center， First Affiliated Hospital of Wenzhou Medical University， Wenzhou 325035， China; 2 Eye Hospital， Wenzhou Medical University， Wenzhou 325035， China)
    

Abstract: Abstract: The retinal pigment epithelium (RPE) cells play important roles in eye development and visual functions. RPE cells have the functions of secreting growth factor， antioxidant， involving in metabolism of visual cycle， maintaining the blood-retinal barrier， phagocytosis of detached photoreceptor outer segments and other physiological functions. RPE normality is essential for photoreceptor development and normal functions， and defects in RPE cell structure or functions will cause photoreceptor dysfunction and retinal degeneration. Recent studies have revealed new insights into important roles of RPE cells in related eye diseases. In this viewpoint， we provide an overview of some of the current understanding of RPE normal structure and functions and their roles in the development of related eye diseases.
    Key words: retinal degeneration; RPE; pigment cell; eye disease