《生命科学》 2011, 23(1): 81-85

白斑综合症病毒感染相关蛋白质相互作用的研究进展

左华丽¹，金春英²，王　蔚^1*

1 国家海洋局第三海洋研究所海洋生物遗传资源重点实验室，厦门361005；2 华侨大学化工学院，厦门361021

摘　要：摘　要：白斑综合症病毒(white spot syndrome virus，WSSV)是危害对虾的主要病原，给全球水产养殖业带来了巨大经济损失，但至今仍未发现有效的防治方法。研究病毒与宿主的相互作用对于深入了解病毒的致病机理和宿主的免疫机制，从而寻找合适的抗病毒措施具有非常重要的理论意义和实际应用价值。该文主要介绍了蛋白质相互作用的研究方法，以及WSSV 病毒蛋白之间、病毒—宿主蛋白之间和宿主蛋白之间相互作用的研究进展，为有效地防治WSSV 及相关科研提供参考。
    

Advances of proteins interaction involved in white spot syndrome virus infection

ZUO Hua-Li¹， JIN Chun-Ying² ， WANG Wei^1*

1 Third Institute of Oceanography， State Oceanic Administration (SOA)， Xiamen 361005， China; 2 College of Chemical Engineering， Huaqiao University， Xiamen 361021， China

Abstract: Abstract: White spot syndrome virus (WSSV) is the causative agent of white spot syndrome disease of cultured penaeid shrimp. It causes high mortalities and severe damage to the global shrimp culture industry. So far， there is no efficient approach to control this virus. Research on the interaction of proteins encoded by virus and host can help to understand the pathopoiesis mechanism of virus infection and immune system of the host. The knowledge can provide promising strategies for protection and treatment of viral disease. This article mainly presented the approaches employed to analyze protein-protein interaction， the advances of protein interactions involved in WSSV infection，aiming to provide a useful reference for the disease control and the interrelated research．