《生命科学》 2013, 25(1): 28-35

IL-17+γδT细胞与疾病关联性的研究进展

周晓薇¹，胡朝英²，张冬青^1*

(1 上海交通大学医学院，上海市免疫学研究所，上海 200025；2 上海市徐汇区中心医院，上海 200031)

摘　要：摘　要：γδT细胞是一群异质细胞，人和小鼠不同组织部位的γδT细胞亚群表型多变、功能丰富。γδT细胞经过胸腺选择，形成IL-17+γδT细胞、IFN-γ+γδT细胞或IL-4+γδT细胞，它的分化受到很多因素的调控。γδT细胞是炎症介质IL-17的重要来源，IL-17+γδT细胞可以参与多种疾病的诱发和发展，如过敏、自身免疫性疾病，甚至恶性肿瘤。此外，它们也在宿主防御中发挥保护作用，防治传染病和诱导细胞毒性T淋巴细胞对癌症的反应。就IL-17+γδT细胞的发育、分化和调节机制以及在各种疾病中的作用进行综述。
关键词：γδT细胞；IL-17；分化；感染；自身免疫性疾病；肿瘤

Research progress of IL-17 producing- γδT cell in disease

ZHOU Xiao-Wei¹， HU Chao-Ying²， ZHANG Dong-Qing^1*

(1 Shanghai Institute of Immunology， Shanghai JiaoTong University School of Medicine， Shanghai 200025， China; 2 Central Hospital of Xuhui District， Shanghai 200031， China)

Abstract: Abstract: γδT cells are a group of cells of high heterology， which can be divided into several phenotypic and functional categories. Through an unique thymic selection， γδT cells differentiate into IL-17 +γδT cells， IFN-γ+ γδT cells or IL-4+γδT cells， which is influenced by many factors. γδT is a source of IL-17， which is an important mediator of inflammation. IL-17+γδT cells participate in a variety of diseases， such as allergies， autoimmune disease and malignant tumor. In addition， they also play a protective role in host defense， promoting the response of CTLs to cancer. This paper reviewed IL-17+γδT cell development， differentiation and regulation mechanism as well as its roles in various diseases.
Key words: γδT cell; IL-17; differentiation; infection; autoimmune disease; tumor