《生命科学》 2012, 24(4): 321-327

鱼类β-防御素的研究进展

郭洪燕，杨桂文，安利国^*

(山东师范大学生命科学学院，山东省动物抗性生物学重点实验室，济南 250014)

摘　要：摘　要：β-防御素是一种具有六个保守的半胱氨酸位点的阳离子两亲性小分子多肽，是抗菌肽的重要成员。随着基因组学研究的不断深入，目前在鱼类中发现了20个β-防御素基因，其基因结构均是由3个外显子和2个内含子组成，并且具有广谱抗菌活性及抗病毒活性。主要从分子结构、组织分布、基因结构、生物学活性以及生物进化等方面对鱼类β-防御素的研究概况进行综述。
关键词：鱼类；β-防御素；基因结构；生物学活性；生物进化

Research advances in fish β-defensins

GUO Hong-Yan， YANG Gui-Wen， AN Li-Guo^*

(Shandong Provincial Key Laboratory of Animal Resistance Biology， College of Life Sciences， Shandong Normal University， Ji’nan 250014， China)

Abstract: Abstract: β-defensins as one significant member of antimicrobial peptides (AMPs)， are characterized by small， cationic and amphipathic with six conserved cysteine residues. With the development of genomics， twenty β-defensin genes have been found in fish up to now. They， which lyse a broad spectrum of pathogens such as bacteria and viruses， all have the same gene organisation within the coding region of three exons and two introns. This article will summarize the research achievement of β-defensins from its structure， tissue distribution， gene structure， biological activity to biological evolution.
Key words: fish; β-defensin; gene structure; biological activity; biological evolution