《生命科学》 2012, 24(3): 250-254

TNF-α在癌症中的作用研究进展

向春艳¹，何小燕²，李逐波^2*，刘衍季²，赖翔宇²

(1 西南大学动物科技学院，重庆 400716；2 西南大学药学院，重庆 400716)

摘　要：

1004-0374(2012)03-0250-05

    

摘　要：肿瘤坏死因子-α (tumor necrosis factor-α， TNF-α) 是具有多种生物学效应的细胞因子。机体内适量的TNF-α 在抵抗病原菌和肿瘤防御中起着重要的作用，但当其超过一定量时，TNF-α 与其他炎性因子一起反而能促进癌症的发生发展及产生多种病理性损伤。就TNF-α 在癌症中的双重作用及其临床研究现状作一综述。
关键词：TNF-α ；抗癌作用；促癌作用；临床研究
中图分类号：Q51; R730.5 文献标志码：A

Recent advance in the role of TNF-α in cancer

XIANG Chun-Yan¹， HE Xiao-Yan²， LI Zhu-Bo^2*， LIU Yan-Ji²， LAI Xiang-Yu²

(1 College of Animal Sciences and Technology Southwest University， Chongqing 400716， China; 2 College of Pharmaceutical Sciences Southwest University， Chongqing 400716， China)

Abstract:
Abstract: TNF-α， a major inflammatory cytokine with various biological activities such as maintenance and homeostasis of host defence and the immune system， has now been shown to involve in malignant disease and pathological injury when it is excessive. This article will discuss the two paradoxical roles and clinical  research of TNF-α in tumor.
Key words: TNF-α; anti-tumor; pro-tumor; clinical research