《生命科学》 2012, 24(3): 242-249

HLA-G与肿瘤研究进展

阮嫣赟，颜卫华，林爱芬^*

(温州医学院附属浙江省台州医院中心实验室，临海 317000)

摘　要：1004-0374(2012)03-0242-08

摘　要：人类白细胞抗原-G(human leukocyte antigen G， HLA-G) 属于非经典的HLA I 类分子，是机体内重要的免疫耐受分子。HLA-G 可以与表达在免疫细胞上的受体结合直接发挥免疫抑制功能，同时通过诱导产生调节性T 细胞(regulatory T cells， Treg) 或“Trogocytosis”机制参与机体的免疫耐受，以协助肿瘤细胞实现免疫逃逸。近年来研究发现，HLA-G 在多种恶性肿瘤中均存在异常表达并抑制宿主的抗肿瘤免疫反应。对HLA-G 在肿瘤中的表达及可能的作用机制研究进展作一综述。
关键词：HLA-G ；肿瘤；免疫耐受
中图分类号：R392.1; R73-36 文献标志码：A

Recent progress of HLA-G in cancer

RUAN Yan-Yun， YAN Wei-Hua， LIN Ai-Fen^*

(Laboratory Center， Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province， Linhai 317000， China)

Abstract: Abstract: Human leukocyte antigen-G (HLA-G)， a non-classical HLA class I molecule， is an important immunotolerant. HLA-G could directly inhibit biological functions of immune cells by binding to receptors expressed in these cells， and HLA-G-mediated immune tolerance could be extended to induce regulatory T cells (Tregs) and by the mechanism of “Trogocytosis”. To date， HLA-G expression in malignancies has been intensively investigated. We here discuss current findings on HLA-G expression and its possible mechanisms in malignancies.
Key words: HLA-G; cancer; immune tolerance