《生命科学》 2012, 24(3): 228-235

AOM/DSS模型与炎症相关癌变研究进展

林凯璇¹，瞿秀华²，赵晓航^2，3*

(1 南方医科大学，广州 510515；2 中国人民解放军海军总医院，北京 100048；3 中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室，北京 100021)

摘　要：1004-0374(2012)03-0228-08
摘　要：氧化偶氮甲烷(azoxymethane， AOM)/ 葡聚糖硫酸钠(dextran sodium sulfate， DSS) 小鼠模型是一种在致癌剂AOM 和致炎剂DSS 协同作用基础上，由炎症性肠病(inflammatory bowel disease， IBD) 逐步发展为结直肠癌的炎症相关性癌症的研究模型。AOM/DSS 模型能很好地模拟慢性肠道炎症诱发癌症的生理病理过程，近年来被广泛用于炎症相关性癌症形成机制的研究。简要综述AOM/DSS 模型与炎症相关性癌症癌变机理的研究进展。
关键词：动物模型；氧化偶氮甲烷/ 葡聚糖硫酸钠；炎症相关癌症形成
中图分类号：R-332 ；R73-3 文献标志码：A

Advances in research of inflammation-associated carcinogenesis based on the AOM/DSS murine model

LIN Kai-Xuan¹， QU Xiu-Hua²， ZHAO Xiao-Hang^2，3*

(1 Southern Medical University， Guangzhou 510515， China; 2 Navy General Hospital of Chinese PLA， Beijing 100048， China; 3 State Key Laboratory of Molecular Oncology， Cancer Institute， Chinese Academy of Medical Sciences， Beijing 100021， China)

Abstract: Abstract: The azoxymethane (AOM)/ dextran sodium sulfate (DSS) murine model is a kind of inflammationassociated colorectal cancer model， which is based on the combination use of carcinogen AOM with the inflammatory agent DSS and characterized by progressing gradually from inflammatory bowel disease (IBD) to colorectal cancer. Since it can well simulate the physiological and pathological processes of chronic intestinal inflammation-induced cancer， it has been widely utilized to investigate the formation mechanisms of inflammationassociated cancers in recent years. This review briefly summarizes current advances in the AOM/DSS model and its experimental study of the mechanisms of inflammation-associated carcinogenesis.
Key words: animal model; AOM/DSS; inflammation-associated carcinogenesis