《生命科学》 2012, 24(3): 223-227

RNA干扰引起的非特异性免疫反应及其机制研究探讨

吴江锋^1，2，张贺吉¹，柳长柏^1*

(1 三峡大学分子生物学研究所，宜昌 443002；2 三峡大学医学院，宜昌 443002)

摘　要：1004-0374(2012)03-0223-05

摘　要：基因的表达失控是疾病发生的主要原因之一，干扰靶基因的表达可能成为有效的治疗手段。RNA干扰技术是近年兴起的基因调控干预方法，其基础，特别是应用研究极受关注，人们期待RNA 干扰能成为肿瘤、病毒感染等难治疾病的临床治疗手段。然而，这一新兴技术在应用研究过程中显现出诸多问题，如细胞毒性、引起机体非特异性反应等等。就RNA 干扰引起的非特异性免疫反应展开综述，探讨其机制，期望为RNA 干扰的应用研究提供一些思考。
关键词：RNA 干扰；小干扰RNA ；非特异性免疫
中图分类号：Q291; Q52 文献标志码：A

Study in non-specific immune response and mechanisms induced by RNA interference

WU Jiang-Feng^1，2， ZHANG He-Ji¹， LIU Chang-Bai^1*

(1 Molecular Biology Institution of China Three Gorges University， Yichang 443002， China; 2 School of Medical Science of the China Three Gorges Univisity， Yichang 443002， China)

Abstract:

Abstract: Since unregulated gene expression is one of the main causes of diseases， interfering of target gene expression may become an effective treatment method. RNA interference technology has already been a method of  gene regulation in recent years and lots of people have expected that RNA interference technology can be applied to deal with diseases such as tumor and viral infection. But in the process of its application， the RNA interference technology has faced some deficiencies such as cytotoxicity and a series of non-specific reaction in the body and so on. This paper reviews briefly relevant reports of the non-specific immune reactions and their mechanisms induced by the RNA interference.

    

Key words: RNA interference; siRNA; non-specific immunity