《生命科学》 2012, 24(1): 37-42

胚胎干细胞诱导分化为雄性生殖细胞的研究进展

孙　敏，施青青，李碧春^*

(扬州大学动物科学与技术学院，江苏省动物繁育与分子设计重点实验室，扬州 225009)

摘　要：摘　要：胚胎干细胞(embryonic stem cells， ES细胞)具有自我更新及无限分化潜能，理论上可以分化为生殖细胞。目前，在人及鼠中已有体外诱导ES细胞分化为成熟精子的报道。系统阐述影响ES细胞分化为雄性生殖细胞的内源性及外源性因素，并结合国内外最新研究进展总结其诱导分化方法，展望应用前景，期望为从事相关研究的学者提供参考。
关键词：胚胎干细胞；诱导；雄性生殖细胞

Research progress on differentiation of embryonic stem cells into male germ cells

SUN Min， SHI Qing-Qing， LI Bi-Chun^*

(Key Laboratory of Animal Breeding Reproduction and Molecular Design of Jiangsu Province， College of Animal Science and Technology， Yangzhou University， Yangzhou 225009， China)

Abstract: Abstract: Embryonic stem cells (ESCs) have the potential ability of unlimited differentiation and self-renewal. ESCs can differentiate into germ cells in theory. At present， a successful report has been shown that human or mouse ESCs could be induced into mature sperm in vitro. This study aims to systematically describe the endogenous and exogenous factors inducing ESCs differnentiate into male germ cells， meanwhile， the inducing method was summarized combing with the latest research progress home and abroad. In addition， the applying prospect of inducing ESCs into male germ cell was analyzed too in order to provide the evaluable information for the scholars engaged in related research.
Key words: embryonic stem cells; differentiation; male germ cell