《生命科学》 2012, 24(1): 13-18

肌动蛋白解聚因子/cofilin功能的研究进展

徐　阳，原丽平，陈金铃，黄晓红^*

(福建师范大学生命科学学院，福建省发育与神经生物学重点实验室，福州 350108)

摘　要：摘　要：肌动蛋白解聚因子(actin depolymerizing factor， ADF)/cofilin家族是一类肌动蛋白结合蛋白，它们通过切断肌动蛋白纤丝并结合到肌动蛋白单体上，在重塑肌动蛋白骨架中发挥重要作用。就ADF/cofilin家族的结构特点、调控肌动蛋白动力学的机制及其功能的最新研究进展做一简要综述，并指出了目前在ADF/cofilin功能研究方面的不足和尚需解决的问题。
关键词： ADF/cofilin家族蛋白；调控机制；功能

Research progress on functions of ADF/cofilin

XU Yang， YUAN Li-Ping， CHEN Jin-Ling， HUANG Xiao-Hong^*

(Fujian Key Laboratory of Developmental and Neurobiology， College of Life Science，Fujian Normal University， Fuzhou 350108， China)

Abstract: Abstract: The actin depolymerizing factor/cofilins are a family of actin-binding proteins， which remodel the actin
cytoskeleton through severing actin filaments and binding to actin monomers.The structural features of ADF/cofilin
family and regulatory mechanism of actin dynamics were reviewed in this paper， the new progress on functions of
ADF/cofilin were also clarified in detail. It was proposed that there existed deficiency and some unsolved problems
in the research on the functions of ADF/cofilin.
Key words: ADF/cofilin family; regulatory mechanism; function