《生命科学》 2011, 23(8): 796-803

脂肪组织蛋白质组学研究进展

刘春东，王宇祥，王　宁，李　辉^*

(东北农业大学动物科学技术学院，哈尔滨 150030)

摘　要：摘　要：脂肪组织不仅是机体的能量储存库，而且也是重要的内分泌器官。脂肪组织分泌多种激素和细胞因子，参与调节机体多种生理和病理过程。目前飞速发展的蛋白质组学技术，为深入研究脂肪发育的分子机制及其代谢紊乱发生的遗传机理提供了有力的工具。对蛋白质组学在脂肪组织中的研究进展进行了综述，为脂肪组织的发育调控及代谢疾病的治疗提供了新的思路。
关键词：脂肪组织；蛋白质组学；脂肪细胞分化；肥胖症

Research advances on proteomics of adipose tissue

LIU Chun-Dong， WANG Yu-Xiang， WANG Ning， LI Hui^*

(College of Animal Science and Technology， Northeast Agricultural University， Harbin 150030， China)

Abstract: Abstract: Adipose tissue not only maintains energy balance， but also functions as a crucial endocrine organ. It can secrete different kinds of hormones and cytokines that involved in many physiological and pathological processes. The rapid developing proteomic technologies provides powerful tools for our understanding of the mechanisms of adipose development and obesity. This review summarizes research progresses on molecular mechanisms of adipose tissue development， which provide new ideas for the regulation development of adipose tissue and treatment of metabolic disease.
Key words: adipose tissue; proteomics; adipocyte differentiation; obesity