《生命科学》 2011, 23(8): 767-772

Reg基因蛋白家族的研究进展

刘　凤¹，孙子林²，陈平圣¹，李　玲^2*

(1 东南大学医学院病理教研室，南京 210009；2 东南大学附属中大医院内分泌科，南京 210009)

摘　要：摘　要：Reg基因蛋白(regenerating gene protein)属于钙依赖的植物血凝素超家族，其功能类似应激蛋白、抗凋亡因子或生长因子。Reg基因蛋白的促进胰岛β细胞分裂和诱导再生作用最早是在糖尿病研究中被发现。Reg基因蛋白在人体多种组织中均表达，与细胞增殖、炎症创伤、感染和神经系统发育关系密切。随着研究的深入，Reg基因蛋白在胰腺损伤修复、神经系统损伤、消化系统肿瘤、脓毒血症及其他疾病中的作用逐渐引起人们重视。
关键词：Reg基因蛋白；胰腺炎；糖尿病；肿瘤

Advances in regenerating gene protein family

LIU Feng¹， SUN Zi-Lin²， CHEN Ping-Sheng¹， LI Ling^2*

(1 Department of Pathology， Medical School of Southeast University， Nanjing 210009， China; 2 Department of Endocrinology， Zhongda Hospital， Southeast University， Nanjing 210009， China)

Abstract: Abstract: Regenerating gene proteins (Reg) belong to the calcium-dependent lectin gene superfamily， which act as stress proteins， anti-apoptotic factors， and growth factors. It can induce islet β cell proliferation and promote regeneration， which were initially revealed in the study of diabetes. Reg are expressed in various tissues and involved in cellular proliferation， inflammation， infection and neural development. In recent years， the new role of reg in pancreatic repair， neuronal regeneration，  gastrointestinal cancers， and sepsis has spawned significant scientific interests.
Key words: regenerating gene protein; pancreatitis; diabetes; tumor