《生命科学》 2011, 23(6): 592-597

糖链的化学合成

王　玥，叶新山^*

(北京大学天然药物及仿生药物国家重点实验室，北京100191)

摘　要：摘　要：作为生物大分子之一，糖链的研究还没有像蛋白质和核酸那样深入。现阶段糖链的获得仍然存在很大的挑战，阻碍了糖生物学的发展。鉴于通过分离手段得到所需的糖链很困难，酶法合成糖链亦存在着诸多问题，因此目前化学方法合成糖链是最佳的选择。对近年来糖链的化学合成所取得的最新进展进行简要的介绍，主要包括一釜合成、固相合成和标签辅助的合成三个方面。
关键词：寡糖；化学合成；一釜合成；固相合成；氟固相萃取；糖基化反应；糖
中图分类号：Q53 文献标志码：A

Chemical synthesis of oligosaccharides

WANG Yue， YE Xin-Shan^*

(State Key Laboratory of Natural and Biomimetic Drugs， Peking University， Beijing 100191， China)

Abstract: Abstract: Carbohydrate， one of the three major biomolecules， is less studied than protein and nucleic acid. It still remains a challenge to get pure oligosaccharides for biological studies. Since isolation of oligosaccharides is tedious and enzymatic preparation of oligosaccharides is also problematic， chemical synthesis of oligosaccharides is the most popular approach at current stage. This review will summarize the latest advances in chemical oligosaccharide synthesis including one-pot synthesis， solid-phase synthesis， and tag-assisted synthesis.
Key words: oligosaccharide; chemical synthesis; one-pot synthesis; solid-phase synthesis; fluorous solid-phase extraction; glycosylation; carbohydrate