《生命科学》 2011, 23(5): 477-481

成骨细胞中经典Wnt/β-catenin通路研究进展

许　兵¹，刘　慧¹，许应星¹，吴　岩¹，肖鲁伟¹，童培建^2*

(1 浙江中医药大学第一临床医学院，杭州 310053；2 浙江省中医院骨伤科，杭州 310012)

摘　要：摘　要：Wnt/β-catenin经典通路在成骨细胞的分化增殖中起着重要作用。目前研究表明，调节任何一个经典Wnt/β-catenin信号转导通路中的因子都能影响成骨细胞的分化增殖。总结经典Wnt/β-catenin通路中各个因子与成骨细胞分化增殖的关系，以便进一步具体深入研究经典Wnt/β-catenin通路对成骨细胞的影响。
关键词：成骨细胞；Wnt/β-catenin；因子  

Development of the classic Wnt/β-catenin pathway in osteoblasts

XU Bing¹， LIU Hui¹， XU Ying-Xing¹， WU Yan¹， XIAO Lu-Wei¹， TONG Pei-Jian^2*

(1The First College of Clinic Medicine， Zhejiang Traditional Chinese Medical University， Hangzhou 310053， China; 2 Orthopedics， Chinese Medicine Hospital of Zhejiang Province， Hangzhou 310012， China)

Abstract: Abstract: The classical Wnt/β-catenin pathway plays an important role in the differentiation and proliferation of osteoblasts. Now the researches show that the regulation of any factors in classical Wnt/β-catenin signal transduction pathway can influence the differentiation and proliferation of osteoblasts. This paper summarizes the relationship between the respective factors in the classic Wnt/β-catenin pathway and the differentiation and proliferation of osteoblasts in order to further study the classical Wnt/β-catenin pathway of osteoblasts.
Key words: osteoblast; Wnt/β-catenin; factor