《生命科学》 2011, 23(5): 449-453

共刺激分子与宫颈癌相关性的研究进展

赵　琳¹，李志英^1﹡，刘朝奇²

(1 三峡大学第二临床医学院，宜昌 443002；2 三峡大学分子生物学研究所，宜昌 443002)

摘　要：摘　要：共刺激分子是T细胞激活的第二信号，有促进T细胞生长、分化和细胞因子产生的正调控分子，也包括诱导和维持T细胞免疫耐受以至凋亡的负调控分子。将从这两方面对共刺激分子在肿瘤免疫，尤其在宫颈癌中的相关研究方面进行综述。
关键词：共刺激分子；肿瘤；免疫；宫颈癌

The advances of costimulatory molecules and cervical cancer

ZHAO Lin¹， LI Zhi-Ying^1﹡， LIU Chao-Qi²

(1 Ren-he Hospital， China Three Gorges University， Yichang 443002， China;2 Insitute of Molecular Biology， China Three Gorges University， Yichang 443002， China)

Abstract: Abstract: Costimulatory molecules are the second signal for the activation of T cell. These costimulatory molecules not only provide critical positive signals that stimulate T cell growth， promote T cell differentiation and up-regulate cytokine production， but also contribute key negative signals that induce and maintain T cell immune tolerance， even to apoptosis. This article reviews the advances of costimulatory molecules in the tumor immunity， especially in the cervical cancer.
Key words: costimulatory molecules; tumor; immunity; cervical cancer