《生命科学》 2011, 23(5): 423-428

社会互作奖赏效应的多巴胺依赖机制

王建礼^1，2*，邰发道²，赵清梅¹

(1 北方民族大学生物科学与工程学院，银川 750021；2 陕西师范大学生命科学学院，脑与行为科学研究所，西安 710062)

摘　要：摘　要：社会性玩耍、配偶联系和母子联系等亲密社会互作会激活中脑-边缘-皮质多巴胺(DA)系统(mesocorticolimbic dopamine system， MCLDS)，促进DA传递。阿片肽、催产素(oxytocin， OT)和加压素(vasopressin， AVP)能够促进亲密的社会互作，并通过调制DA的活动，提高社会互作的奖赏价值。社会互作和滥用药物之间相互影响，阿片肽、OT和AVP系统是两者交互作用的重要枢纽。揭示两者交互作用的神经机制，对于开展精神疾病或成瘾戒断的治疗有重要指导意义。
关键词：奖赏；社会联系；成瘾；多巴胺；神经肽

Involvement of dopamine-dependent mechanisms in the rewarding effects of social interactions

WANG Jian-Li^{1， 2*}， TAI Fa-Dao²， ZHAO Qing-Mei¹

(1 College of Life Sciences and Engineering， Beifang University of Nationalities， Yinchuan 750021， China; 2 Institute of Brain and Behavioral Sciences， College of Life Sciences， Shaanxi Normal University， Xi’an 710062， China)

Abstract: Abstract: The mesocorticolimbic dopamine (DA) system can be activated by close social interactions (e.g. social play， pair bonding and mother-offspring bonding)， leading to DA neurotransmission. Opioids， oxytocin (OT) and vasopressin (AVP) can facilitate close social attachment and enhance the reward value by mediating DA activity. There are reciprocal interactions between social interactions and drug abuse， in which opioids， OT and AVP systems play a pivotal role. Elucidating the neural mechanisms underlying such interactions will help us to develop novel treatments for psychiatric disorders and addiction withdrawal.
Key words: reward; social interactions; addiction; dopamine; neuropeptide