《生命科学》 2011, 23(4): 385-389

五羟色胺转运体的研究进展

范东芬，奚耕思^*，梁开丹，张武会

(陕西师范大学生命科学学院，动物生殖与发育实验室，西安 710062)

摘　要：摘　要：五羟色胺转运体是一种对5-羟色胺(5-HT， serotonin)有高度亲和力的跨膜转运蛋白，能够重新摄取细胞间隙内的5-HT，从而调节神经信号的转导。该文简述了五羟色胺转运体的生物学特性、分布以及与人类疾病的关系，通过分析比较发现，五羟色胺转运体的多态性与肠易激综合症、抑郁症、强迫症都有着密切的关系。
关键词：5-羟色胺；5-羟色胺转运体；基因多态性；抑郁症

Serotonin transporter progress

FAN Dong-Fen， XI Geng-Si^*， LIANG Kai-Dan， ZHANG Wu-Hui

(College of Life Science， Shaanxi Normal University， Xi’an 710062， China)

Abstract: Abstract: 5-Hydroxytamine transporter(SERT) is a kind of transmembrane transporter that has high affinity with 5-HT and can intake 5-HT in the intercellular space. Then SERT can regulate the transduction of neuronal signals. This paper illustrated the bionomics and distribution of SERT， and the relation to the diseases of human. Many investigation found that the polymorphism of the SERT may be related to irritable bowel syndrome， depression and obsessive compulsive disorder.
Key words: serotonin; serotonin transporter; gene polymorphism; depression