《生命科学》 2011, 23(1): 86-89

干扰程序性死亡分子1及其配体信号通路的免疫治疗

汪龚泽，刘朝奇^*

三峡大学分子生物学研究所，宜昌 443002

摘　要：摘　要： 程序性死亡分子1(programmed death-1， PD1)及其配体(programmed death ligand， PDL)属于B7家族的共刺激分子，介导免疫反应的负性调节信号，在肿瘤发生、病毒感染以及自身免疫病中都发挥了特异性的调节作用。利用PD1/PDL1信号途径调节机体的免疫应答从而达到免疫治疗的目的，该文就此展开综述。
关键词：PD1；PDL1；免疫调节；免疫治疗

A therapeutic strategy of targeting PD1/PDL signal pathway

WANG Gong-Ze， LIU Chao-Qi^*

Institute of Molecular Biology， Three Gorges University， Yichang 443002， China

Abstract: Abstract:  PD1(programmed death-1， PD1)and PDL1(programmed death ligand-1， PDL1) are members of co-stimulating molecules of B7 superfamily. PDL1 binds to PD-1， which  mainly expresses on the activated T cells， mediates the negative modulating signals. Interfering the PD1/PDL signal pathway regulates the immunological responses， which could be used as a therapeutic strategy for cancer， viral infection and auto-immune diseases. In this paper， we reviewed the current progress of the associated research.
Key words: PD1; PDL1; immuno-regulation; immunotherapy