《生命科学》 2011, 23(1): 77-80

动物关键模式识别受体及其抗病毒天然免疫作用研究进展

李国勤，卢立志^*

浙江省农业科学院畜牧兽医研究所，杭州 310021

摘　要：摘　要：天然免疫系统是动物抵御病原入侵的第一道防线，在机体抗病毒感染过程中发挥重要作用，模式识别受体(pattern-recognition receptors，PRRs)是天然免疫系统的重要成分，动物机体的抗病毒免疫机制是由一系列PRRs对病原体的识别所启动的。近年来识别和感受病原体的一系列动物PRRs受到广泛关注，成为动物医学领域的研究热点，为揭示动物复杂的抗病毒天然免疫反应提供了新思路。该文简要介绍动物Toll样受体(Toll-like receptors，TLRs) 和维甲酸诱导基因Ⅰ样受体(RIG-I like receptors，RLRs)的分子特征及其介导的抗病毒天然免疫作用研究进展。
关键词：动物；模式识别受体；天然免疫；抗病毒

Research advances on major pattern-recognition receptors and their innate immune responses against virus invasion in animals

LI Guo-Qin， LU Li-Zhi^*

Institute of Animal Science and Veterinary Medicine， Zhejiang Academy of Agricultural Sciences， Hangzhou 310021， China

Abstract: Abstract: The innate immune system is responsible for early detection of potentially pathogenic microorganisms and plays an important role in the process of host defence against virus invasion. Pattern-recognition receptors (PRRs) are important components of the innate immune system， enabling early detection of pathogenic infection. In recent years， the various members of the different PRR families are recognized and become currently a hot subject of research in veterinary medicine， which provide important information about the role of PRRs in the complex mechanism of the innate immune against viruses in animals. In the present article， the molecular traits of Toll-like receptors(TLRs) and RIG-I like receptors(RLRs) and their innate immune responses against virus infection in animals are briefly introduced.
Key words: animal; pattern-recognition receptor; innate immune; anti-virus response