《生命科学》 2011, 23(1): 7-12

局部黏着斑激酶作为肿瘤治疗靶点的研究进展

张文静¹，黄启来^1*，华子春^1，2*

1澳门科技大学中医药学院和澳门药物及健康应用研究所，澳门; 2 南京大学医药生物技术国家重点实验室，南京210093

摘　要：摘　要：局部黏着斑激酶(focal adhesion kinase， FAK)是一种非受体型酪氨酸蛋白激酶，是细胞内重要的骨架蛋白与多种信号通路的关键分子。FAK在肿瘤发生、发展、迁移和侵袭的各个阶段都具有重要作用，FAK已经被当作潜在的肿瘤治疗靶点来研究。该综述将对FAK与肿瘤的关系以及FAK作为肿瘤治疗靶点的研究进展进行探讨。
关键词：局部黏着斑激酶；抗肿瘤；治疗

Focal adhesion kinase， a novel target for cancer therapy

ZHANG Wen-Jing¹， HUANG Qi-Lai^1*， HUA Zi-Chun^{1， 2*}

1Faculty of Chinese Medicine and Macau Institute for Applied Research in Medicine and Health， Macau University of Science and Technology， Macau， China; 2The State Key Laboratory of Pharmaceutical Biotechnology， Nanjing University， Nanjing 210093， Chi

Abstract: Abstract: Focal adhesion kinase (FAK)， a cytoplasmic non-receptor protein tyrosine kinase， serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways. FAK is involved in tumor cell survival， proliferation， migration and metastasis. Currently， FAK has been regarded as a potential target for cancer therapy. This review is to summarize the relationship between FAK and tumor progression， and to discuss the strategies targeting FAK for cancer treatment.
Key words: focal adhesion kinase; antitumor; treatment