《生命科学》 2011, 23(1): 1-6

Akt/PKB抗凋亡机制与天然活性物质的抗肿瘤作用

刘玉梅¹，祖桂芳²，赵晓红^1*，梅　晶¹

1北京联合大学应用文理学院，北京 100191；2 首都师范大学生物科学学院，北京100037

摘　要：摘　要：Akt/PKB是调控细胞生存与凋亡的重要信号物质之一。它能够影响下游多种效应分子的活化状态，在细胞内发挥着抑制细胞凋亡、促进细胞增殖的作用，并同人类多种肿瘤的发生发展密切相关。天然活性物质能够通过抑制Akt/PKB通路、诱导细胞凋亡来发挥它们的抗肿瘤效应。对Akt/PKB与细胞凋亡关系的研究不但有利于理解细胞凋亡机制，还可以指导开发新型的抗癌活性物质。本文综述了Akt/PKB对细胞凋亡、存活的调节机制及天然活性物质通过PI3K/Akt信号通路抗肿瘤作用的研究进展。
关键词：Akt/PKB；细胞凋亡；信号通路；抗肿瘤；天然活性物质

The anti-apoptosis mechanisms of Akt/PKB and anti-tumor effects of natural active substances

LIU Yu-Mei¹， ZU Gui-Fang²， ZHAO Xiao-Hong^1*， MEI Jing¹

1 College of Applied Arts and Sciences， Beijing Union University， Beijing 100191， China; 2 College of Life Science， Capital Normal University， Beijing 100037， China

Abstract: Abstract: Akt/PKB is one of the important signal molecules， which play a pivotal role in inhibiting apoptosis， promoting proliferation and influencing the activation state of some downstream molecules， and is closely correlated with human tumorigenesis. The anti-tumor effects of natural active substances can be achieved by inhibiting Akt signaling pathway to induce apoptosis. The study of the relationship between Akt/PKB and apoptosis is important， not only for understanding the basic cellular life phenomenon， but also for developing new anticancer active compounds. The mechanisms of Akt/PKB regulation in apoptosis， cell survival and anticancer effects of natural active substances by Akt/PKB signaling pathway were reviewed.
Key words: Akt/PKB;  apoptosis; signal pathway; anticancer; natural active substance