《生命科学》 2010, 22(12): 1247-1253

肥胖相关的肠道微生物群落结构动力学与功能解析研究

赵立平*，张晨虹

(上海交通大学生命科学技术学院，上海 200240)

摘　要：

 

    

摘　要：肥胖及相关的慢性代谢性疾病近年来已经成为威胁全球的公共健康问题。越来越多的证据表明，在宿主的营养、免疫和代谢中有不可替代的作用的肠道菌群不仅可以通过调节宿主脂肪吸收存储相关的基因，影响后者的能量平衡，更重要的是其结构失调导致宿主循环系统中内毒素增加，诱发慢性、低水平炎症，导致肥胖和胰岛素抵抗。运用微生物分子生态学、元基因组学和代谢组学的方法，揭示与代谢性疾病相关的菌群结构失调，并鉴定出相关的特定细菌类群及其功能，使得通过以菌群为靶点的营养干预手段防止慢性代谢性疾病成为可能，将带来代谢性疾病预防和控制策略的革命性的变化。

    

关键词：肠道菌群；内毒素；肥胖；代谢性疾病
中图分类号：R37; R58  文献标识码：A

    

 

Functional dynamics of gut microbiota in obesity and metabolic diseases

ZHAO Li-ping*， ZHANG Chen-hong

(Shanghai Center for Systems Biomedicine， Shanghai Jiao Tong University， Shanghai 200240， China)

Abstract:

Abstract: The prevalence of obesity-related metabolic disorders has become a challenge to public health around the world. As the second genome， gut microbiome can modulate the nutrition， metabolism and immunity of host， Emerging evidence indicates that gut microbiota may thus play an important mediating role between diet， life style and host genetics in development of obesity and eventually many forms of metabolic diseases. Diet-disrupted gut microbiota can lead to increased level of endotoxin， provoke the chronic inflammation and then induce obesity and insulin resistant. Research along this line to reveal the shift of gut microbiota and identify the specific functional groups of bacteria， may lead to discovery of new therapeutic targets and revolutionary strategies for predictive， preventive and personalized management of metabolic disorders.

    

Key words: gut microbiota; endotoxin; obesity; metabolic diseases