《生命科学》 2010, 22(11): 1092-1096

鼠疫菌毒力调控研究

周冬生，杨瑞馥*

军事医学科学院微生物流行病研究所，病原生物安全国家重点实验室，北京 100071

摘　要：摘　要：鼠疫菌通过一系列转录调控子(如CRP、PhoP、RovA 和Fur)控制着一些关键毒力因子(如Pla、强毒力岛、III型分泌系统等)的基因表达。鼠疫菌可感应宿主体内信号刺激，紧密调控毒力因子的表达。在这个紧密调控过程中，调控子、毒力相关基因构成了一个动态网络。鼠疫菌在从假结核菌祖先演化的进程中，基因表达调控网络的重塑在鼠疫菌毒力进化过程中发挥着不可取代的作用。
关键词：鼠疫菌；转录调控；毒力

Studies on virulence regulation of Yersinia pestis

ZHOU Dong-sheng， YANG Rui-fu*

State Key Laboratory of Pathogen and Biosecurity， Institute of Microbiology and Epidemiology， Academy of MilitaryMedical Sciences (AMMS)， Beijing 100071， China

Abstract: Abstract: A set of transcritpional regulators such as CRP， PhoP， RovA and Fur have been characterized to regulate virulence-related genes in Yersinia pestis， especially including those encoding Pla， high pathogenicity island and type III secretion system. Y. pestis has evolved the ability to sense host signals and then to closely regulate the expression of virulence factors， for which regulators and their target virulence-related genes constitute a dynamic gene regulatory network. The remodeling of gene regulatory network promotes the evolution of Y. pestis， which is a deadly pathogen causing systemic infections， from its ancestor Y.  pseudotuberculosis that is a mild enteropathogenic bacterium.
Key words: Yersinia pestis; transcriptional regulation; virulence