《生命科学》 2010, 22(4): 362-366

CD4+CD25+调节性T细胞与肿瘤免疫研究进展

张 妍¹，迟晓燕²，崔保霞^1*

（1 山东大学齐鲁医院妇产科，济南 250012；2 青岛市立医院妇产科，青岛 266011）

摘　要：摘　要：调节性T细胞(Treg)是一类具有免疫调节功能的细胞群，在机体的免疫耐受中起着关键性作用。它们主要通过细胞-细胞直接接触的方式抑制CD4+ 和CD8+ 效应性T细胞的活化和增殖，来调节获得性免疫系统，阻止自身免疫疾病的发生。Treg中以自然产生的CD4⁺CD25⁺ 调节性T细胞(固有Treg细胞)研究最多。在人类，调控效能主要限于CD4⁺CD25^high 亚型。由于Treg独特的生物学功能，它在自身免疫性疾病的发生、移植耐受和肿瘤的发生和转归上越来越受到重视。该文就该类细胞的特点及其与肿瘤关系的研究进展作一综述。
关键词：CD4⁺CD25⁺ 调节性T细胞；肿瘤；免疫治疗；化疗
中图分类号：Q28; R73-36　　文献标识码：A

The research progress of CD4+CD25+ regulatory T cells and the anti-tumor immune

ZHANG Yan¹， CHI Xiao-yan²， CUI Bao-xia^1*

(1 Department of Obstetrics and Gynecology， Affliated Qilu Hospital， Shandong University， Ji{$39}nan 250012， China;2 Department of Obstetrics and Gynecology， Qingdao Municipal Hospital， Qingdao 266071， China)

Abstract: Abstract: Treg(Regulatory T cell) is a kind of cells with immune regulation function， which plays a key role in the immunotolerance. They mainly through cells - cells indirect contacting way inhibit the activation and proliferation of CD4+ and CD8+ effect T cells， and to regulate the acquired immune systems and prevent the occurrence of autoimmune diseases. The most studied Treg cell type is the naturally occurring CD4⁺CD25⁺ regulatory T cells (natural Treg cells). In humans， regulation efficiency mainly is confined to CD4+CD25^high subtype. Due to its unique biological function， Treg in autoimmune disease， transplantation tolerance and cancer{$39}s incidence and prognosis cause more and more attention. In this paper， the characteristics of such cells， and its relationship with tumor research are reviewed.
Key words: CD4⁺CD25⁺ Treg; tumor; immunotherapy; chemotherapy