《生命科学》 2010, 22(6): 506-514

记忆性T细胞的形成、维持和功能

刘　昀，吴长有*

(中山大学中山医学院免疫学教研室，广州510080)

摘　要：摘　要：免疫记忆是指机体在对某一抗原产生特异性识别及应答的同时，记住该抗原，当再次遭遇同一抗原时，能发生快速和强烈的免疫应答。树突状细胞吞噬病原微生物后，通过主要组织相容性复合体分子提呈抗原短肽段，与T细胞相互作用。在T细胞抗原受体信号和共刺激信号的协同作用下，抗原特异性T细胞增殖，收缩，小部分细胞作为记忆细胞长期存活。免疫记忆T细胞在表型特征和功能上都存在多样性。深入研究机体记忆性T细胞的特征，不仅能指导新型疫苗的设计，而且可望帮助治疗疾病。
关键词：T细胞；记忆性；细胞因子
中图分类号：R392.12 文献标识码：A

Generation， maintenance and function of memory T cells

LIU Yun， WU Chang-you*

(Department of Immunology， Zhongshan School of Medicine， Sun Yat-sen University， Guangzhou 510080， China)

Abstract: Abstract: Immunological memory is the ability to make a second and more effective immune response to an antigen that encountered previously. Antigen is processed to short peptides and presented by DCs on MHC molecules to initiate the responses of T cells. A TCR signal with co-stimuli leads to clonal expansion of antigen-specific T cells and follows a phase of contraction， in which most short-lived antigen-specific effector T cells die. Some of these cells survive and form long-lived memory cells. Memory cells are heterogeneous in phenotype and function. Understanding the properties of memory T cells will help in the design of vaccines and the immunotherapy for diseases.
Key words: T cells; memory; cytokine