《生命科学》 2010, 22(8): 788-792

microRNAs与心血管疾病

薛胜将，欧和生*

（南华大学药物药理研究所， 衡阳 421001）

摘　要：摘　要：microRNAs(miRNAs)是一类长21~25 nt的非编码内源性蛋白质的RNAs，它们在转录后水平调控基因的表达，包括细胞增殖、分化和凋亡等一系列生理进程，影响生物体的生长发育，并与多种疾病相关。随着研究人员对microRNAs参与疾病的发病机制的研究，可能为人类某些疾病的治疗开辟一条新的途径。该文总结miRNAs在调控心血管疾病发生作用方面的研究成果，并对miRNA与心肌肥厚、心肌纤维化、心肌梗死、高血压、心率失常等的关系进行综述和展望。
关键词：microRNAs；心血管疾病；心肌肥厚；心肌纤维化；心肌梗死；高血压；心率失常

microRNAs and cardiovascular diseases

XUE Sheng-jiang， OU He-sheng*

(Institute of Pharmacy and Pharmacology， University of South China， Hengyang 421001， China)

Abstract: Abstract: microRNAs (miRNAs) is the term used to describe endogenous and short (21-25 nucleotides long) regulatory RNA molecules that govern gene expression at the post-transcriptional level. They regulate the expression of genes in all kinds of physiological processes including cells proliferation， differentiation and apoptosis etc，and further， they contact with a variety of human diseases. To elucidate the role of miRNAs in diseases，researchers have done lots of researches and pointed out that research results may provide a novel strategy for the therapy of many diseases. This article summarizes the progress in the study on the role of miRNAs in cardiovascular diseases and the relationship between miRNAs and cardiovascular diseases including myocardial hypertrophy， myocardial fibrosis， myocardial infarction， hypertension and arrhythmia etc.
Keywords: microRNAs; cardiovascular diseases; myocardial hypertrophy;  myocardial hypertrophy; myocardial infarction; hypertension; arrhythmia