《生命科学》 2010, 22(3): 284-290

卵黄蛋白原的研究进展

李兆杰¹，杨丽君^1*，王　静¹，时文春¹，刘玉敏¹，鲁太义²

(1威海出入境检验检疫局，威海264205；2山东省威海市第一中学，威海264200)

摘　要：

摘　要：卵黄蛋白原(vitellogenin， Vg)是一种普遍存在于卵生非哺乳动物中的糖磷脂蛋白，其作为一种重要的生殖蛋白参与卵生动物生殖、发育等重要生理过程。最新研究表明，卵黄蛋白原还参与动物的免疫防御过程，是一种典型的模式识别分子。本文系统全面的介绍了卵黄蛋白原的研究进展，包括卵黄蛋白原的激素诱导、合成方式、分解代谢、结构特性以及生物学功能等，此外还详细介绍了其作为生物标志物在环境激素检测中的应用。对卵黄蛋白原近期的研究成果进行综述可为今后开展卵黄蛋白原相关研究提供可靠的参考和指导。
关键词：卵黄蛋白原；卵黄发生；结构；功能；生物标志物

The progress in studies on vitellogenin

LI Zhao-jie¹， YANG Li-jun^1*， WANG Jing¹， SHI Wen-chun¹， LIU Yu-min¹， LU Tai-yi²

(1Weihai Entry-Exit Inspection and Quarantine Bureau， Weihai 264205， China; 2The First Middle School of Weihai， Weihai 264205， China)

Abstract:

Abstract: Vitellogenin (Vg) is a phospholipoglycoprotein universally existing in all oviparous organisms. As a major reproductive protein， Vg involves in the progress of reproduction and development of oviparous animals. In recent years， Vg has attracted increasing attentions. One of the most exciting aspects is the mechanism of its immune defense as a multivalent pattern recognition receptor. This article attempted to present some most recent findings about Vg， including its induction by estrogens， vitellogenesis， degradation， characters of structures and biological functions. Moreover， the application of Vg as an ideal biomarker in detection of environment hormones was expatiated. This review not only provides a great deal of information to understand the rapid progress about Vg， but also helps the further research on Vg.
Key words: vitellogenin; vitellogenesis; structure; function; biomarker