《生命科学》 2010, 22(3): 278-283

肾脏免疫区室化与肾小管间质损伤

陈　静，周　同^*，蔡敏超，林　凯，张彦洁，许春娣

(上海交通大学医学院附属瑞金医院，上海200025)

摘　要：

摘　要：免疫系统区室化(compartmentalization)是近年提出的一个新观念，为人们从整体和局部两方面进一步了解免疫系统提供了新的视角，且有助于对临床疾病免疫机制的阐释。最近肾脏免疫系统区室化现象也已引起人们重视。肾小管损伤和肾间质纤维化是各类肾脏疾病发展到终末期肾衰竭的重要原因和共同通路，也与肾小管间质免疫区室的局部微环境调控密切相关，并涉及区域内树突状细胞等专职免疫细胞，以及具有免疫特性肾小管上皮细胞的共同作用及相互调节，由此影响着肾脏疾病的发生、发展及预后。因此，从肾脏免疫区室化角度进一步探讨肾小管间质损伤机制，有助于深入分析肾脏疾病的病变过程，并可为相关研究及临床诊治提供新的思路。
关键词：免疫系统；区室化；慢性肾脏病；肾小管间质纤维化；免疫调节

The renal immune compartmentalization and the tubulointerstitial injury

CHEN Jing， ZHOU Tong^*， CAI Min-chao， LIN Kai， ZHANG Yan-jie， XU Chun-di

(Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China)

Abstract:

Abstract: Compartmentalization of the immune system is a new concept， providing a new perspective for the better understanding of the immune system， both as a unitary whole and through its regional features. Recently， researchers noticed the compartmentalization in renal immune system. Renal tubular lesion and interstitial fibrosis is the common process of chronic kidney diseases (CKD) developing into end stage renal diseases， and it closely relates with the microenvironmental regulation in the renal tubular compartment. The professional immune cells such as dendritic cells (DC) and the renal tubular epithelial cells (RTEC) with immune properties in this compartment are all involved， they regulate and collaborate with each other， influencing the progression and prognosis of the renal diseases. Thus， clarify the mechanism of the tubulointerstital lesions in the perspective of immune compartmentalization in kidney is in favor of analyzing the pathological process of renal disease as well as providing a new method for concerning research and clinical diagnosis and treatment.
Key words: immune system; compartmentalization; chronic kidney disease; renal tubular interstitial fibrosis; immunoregulation