《生命科学》 2010, 22(2): 129-132

Wnt信号在胚胎干细胞自我更新和分化中的作用

叶守东，谭　理，宋后燕，李　平^*

（复旦大学分子医学教育部重点实验室 上海 200032）

摘　要：摘要：胚胎干细胞分离自胚泡内细胞团，具有无限自我更新和多向分化潜能， 有很大的医学应用前景。Wnt家族是一类分泌型的细胞信号传导蛋白，可以通过复杂的信号传递通路调控胚胎的早期发育，对细胞的分化、增殖及生长具有重要的调节作用。该文就Wnt信号通路调节胚胎干细胞的自我更新和分化作一综述。 
关键词：Wnt信号通路；自我更新；分化   

Role of Wnt signalling in the self-renewal and differentiation of embryonic stem cells

YE Shou-dong， TAN Li， SONG Hou-yan， LI Ping^*

(The Key Laboratory of Molecular Medicine， Ministry of Education， Shanghai Medical College， Fudan University， Shanghai 20032， China)

Abstract: Abstract: Embryonic stem cells， derived from the inner cell mass of blastocysts， hold significant potential for clinical therapies because of their distinctive capacity to both self-renew and differentiate into a wide range of specialized cell types. Wnts comprise a large family of secreted glycoproteins that regulate a variety of developmental changes， including cellular proliferation， differentiation and migration. Here， we will review the importance of the Wnt signalling pathway in regulating the self-renewal and differentiation of embryonic stem cells.
Keywords： Wnt; self-renew; differentiation